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Molecular Radiation Oncology

Kurganovs N#, Wang H#, Huang X, Ignatchenko V, Macklin A, Khan S, Downes MR, Boutros PC, Liu SK*, Kislinger T* (# co-first authors, *Shared Senior Authorship). (2021). A proteomic investigation of isogenic radiation resistant prostate cancer cell lines.  Proteomics Clinical Applications. 2021 In press.

Ray J, Haughey C, Hoey C, Jeon J, Murphy R, Dura-Perez L, McCabe N, Downes M, Jain S, Boutros PC, Mills IG, Liu SK. miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA. Cancer Letters 473:107-117, 2020.

Ray J, Hoey C, Huang X, Jeon J, Taeb S, Downes MR, Boutros PC, Liu SK.  MicroRNA‑198 suppresses prostate tumorigenesis by targeting MIB1.  Oncology Reports 42(3):1047-1056, 2019.

Mesci A, Lucien F, Huang X, Wang EH, Shin D, Meringer M, Hoey C, Ray J, Boutros PC, Leong HS, Liu SK. RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer.  J Transl Med 17(1):125, 2019.

Bhandari V, Hoey C, Liu LY, Lalone E, Ray J, Livingstone J, Lesurf R, Shiah YJ, Vujcic T, Huang X, Espiritu SMG, Heisler LE, Yousif F, Huang V, Yamaguchi TN, Yao CQ, Sabelnykova VY, Fraser M, Chua MLK, van der Kwast T, Liu SK, Boutros PC, Bristow RG. Molecular landmarks of tumor hypoxia across cancer types. Nature Genetics 51(2):308-318, 2019.

Hoey C, Ray J, Jeon J, Huang X, Taeb S, Ylanko J, Andrews DW, Boutros PC, Liu SK. MiRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation. Molecular Oncology. 2018 Aug;12(8):1324-1341.


Ghiam AF, Taeb S, Huang X, Huang V, Ray J, Scarcello S, Hoey C, Jahangiri S, Fokas E, Loblaw A, Bristow RG, Vesprini D, Boutros P, Liu SK.  Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget. 2017 Jan 17; 8(3):4668-4689.

Ghiam AF, Vesprini D, Liu SK. Long non-coding RNAs: New Frontiers for Advancing Personalized Cancer Medicine in Prostate Cancer. Transl Androl Urol 2017; 6(2):326-330. 


Azad A, Lim SY, D’Costa Z, Jones K, Diana A, Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel R, Fokas E. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Mol Med. 2017 Feb; 9(2):167-180.

Huang X, Taeb S, Jahangiri S, Korpela E, Cadonic I, Yu N, Krylov S, Fokas E, Boutros P, Liu SK.  miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD).  Oncotarget 6(26):22439, 2015.


Korpela E, Vesprini D, Liu SK.  MicroRNA in radiotherapy: mirage or miRador?  British Journal of Cancer 112:777, 2015.


Huang X, Taeb S, Jahangiri S, Emmenegger U, Tran E, Bruce J, Mesci A,  Korpela E, Vesprini D, Wong CS, Bristow, RG, Liu FF, Liu SK.  MicroRNA-95 mediates tumor radiation resistance by targeting sphingosine-1-phosphate phosphatase 1.  Cancer Research 73(23):6972, 2013.


Diana A, Wang LM, D'Costa Z, Azad A, Silva MA, Soonawalla Z, Allen P, Liu S, McKenna WG, Muschel RJ, Fokas E. Prognostic role and correlation of CA9, CD31, CD68 and CD20 with the desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget 2016 Nov 8;7(45):72819-72832.

Li Y-Q, Cheng Z, Liu S, Aubert I, Wong S. p53 regulates disruption of neuronal development in adult hippocampus after irradiation. Cell Death Discovery. 2016 Oct 3;2:16072.

Diana A, Wang LM, D’Costa Z, Allen P, Azad A, Silva MA, Soonawalla Z, Liu S, McKenna WG, Muschel RJ, Fokas E. Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. 2016 Jul 5;7(27):40992-41004.

Mesci A, Taeb S, Huang X, Jairath R, Sivaloganathan D, Liu S.  Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma.  World Journal of Gastroenterology 20(46):17376, 2014.

Wang LW, Silva M, D’Costa Z, Bockelmann R, Soonawalla Z, Liu S, O’Neill E, Mukherjee S, McKenna W, Muschel R. The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. 2016 Jan 26;7(4):4183-94.


Liu SK, Bham S, Fokas E, Beech J, Im J, Song C, Harris AL, Muschel RJ.  DLL4-Notch blockade and tumor radiation response. Journal of the National Cancer Institute 103 (23): 1778, 2011.

Translational, Clinical and Experimental Oncology

Khoo A, Liu L, Nyalwidhe J, Semmes OJ, Vesprini D, Downes M, Boutros P*, Liu S*, Kislinger T* (*Shared Senior Authorship). (2021). Proteomic discovery of non-invasive biomarkers for localized prostate cancer using mass spectrometry.  Nature Reviews Urology. 2021; In press.

Wang H, Mendez L, Morton G, Loblaw A, Mesci A, Chung H, Chan S, Huang X, Downes M, Vesprini D, Liu SK. Immune cell profiling in Gleason 9 prostate cancer patients treated with brachytherapy versus external beam radiotherapy: an exploratory study. Radiotherapy and Oncology.  2021; 155:80-85.

Hoey C, Jeyapala R, Boutros PC, Bapat B, Liu SK. Urinary biomarkers in prostate cancer: to the miRnome and beyond. Translational Andrology and Urology. 2020; 9(2):843-845.

Jeon J, Olkov-Mitsel O, Xie H, Yao C, Zhao F, Jahangiri S, Cuizon C, Scarcello S, Jeyapala R, Watson JD, Fraser M, Ray J, Commisso K, Loblaw A, Fleshner NE, Bristow RG, Downes M, Vesprini D, Liu SK*, Bapat B*, Boutros PC* (*co-senior authors). Temporal stability and prognostic biomarker potential of the prostate cancer urine transcriptome.  Journal of the National Institute of Cancer 2020; 1;112(3):247-255.

Hoey C, Musa A, Ghiam AF, Vesprini D, Huang X, Commisso K, Commisso A, Fokas M, Loblaw DA, He HH, Liu SK.  Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy. J Transl Med 17:173, 2019.

Hoey C, Liu SK.  Circulating blood miRNAs for prostate cancer risk stratification: miRroring the underlying tumor biology with liquid biopsies. Res Rep Urol 11:29-42, 2019.

Mesci A, Liu SK. Collagen and Calcium Binding EGF Domains 1 (CCBE1) in cancer - a new role past lymphatics?  Oncoscience 4(11-12): 2017.

Mesci A, Huang X, Taeb S, Jahangiri S, Kim Y, Fokas E, Bruce J, Leong HS, Liu SK.  Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis. British Journal of Cancer 116 (10): 1350, 2017.

Korpela E, Yohan D, Lee C, Kim A, Huang X, Sade S, Van Slyke P, Dumont D, Liu SK.  Vasculotide an Angiopoietin-1 mimetic reduces acute skin ionizing radiation damage in a preclinical mouse model.  BMC Cancer 26 (14): 614, 2014.


Chin L, Cook E, Yohan D, Kim A, Niu C, Wilson BC, Liu SK. Early biomarker for radiation-induced wounds: Day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy. Biomed Optics Exp. 2017 Feb 8(3):1682.

Chin L, Korpela E, Kim A, Yohan D, Niu C, Wilson BC, Liu SK.  Diffuse optical spectroscopy for the quantitative assessment of acute ionizing radiation induced skin toxicity using a mouse model.  J. Vis. Exp.(111), e53573, doi:10.3791/53573, 2016.

Korpela E, Liu SK.  Endothelial perturbations in normal tissue radiation damage and therapeutic strategies.  Radiation Oncology 9:266, 2014.

Karam I, Poon I, Lee J, Liu S, Higgins K, Enepekides D, Sahgal A, Lo SS. Stereotactic body radiotherapy for head and neck cancer: an addition to the armamentarium against head and neck cancer. Future Oncology. 2015 Nov;11(21):2937-2947.

Awan M, Liu S, Sahgal A, Das S, Chao ST, Chang EL, Knisely J, Redmond K, Sohn JW, Machtay M, Sloan AE, Mansur DB, Rogers LR, Lo SS. Extra-CNS metastasis from glioblastoma: a rare clinical entity. Expert Rev Anticancer Ther. 2015;15(5):545-552.

Musunuru HB, Davidson M, Cheung P, Vesprini D, Liu S, Chung H, Chu W, Marnedov A, Ravi A, D’Alimonte L, Commisso K, Helou J, Deabreu A, Zhang L, Loblaw A. Predictive parameters of symptomatic hematochezia following 5-fraction gantry-based SABR in prostate cancer. International Journal of Radiation Oncology Biology Physics. 2016 Apr;94(5):1043-1051.

Morton G, Chung HT, McGuffin M, Helou J, D’Alimonte L, Ravi A, Cheung P, Szumacher E, Liu S, Al-Hanaqta M, Zhang L, Mamedov A, Loblaw A. Prostate high dose-rate brachytherapy as monotherapy for low and intermediate risk prostate cancer: early toxicity and quality-of life results from a randomized phase II clinical trial of one fraction of 19 Gy or two fractions of 13.5 Gy. . Int J Radiat Oncol Biol Phys. 2017 Jan; 122(1):87-92.


Wegman DW, Ghasemi F, Khorshidi A, Yang BB, Liu SK, Yousef GM, Krylov SN. Highly-sensitive amplification-free analysis of multiple miRNAs by capillary electrophoresis.  Analytical Chemistry 87(2):1404, 2015.


El Kaffas A, Nofiele J, Giles A, Cho S, Liu SK, Czarnota G. DLL4-Notch signaling blockade synergizes combined ultrasound-stimulated microbubble and radiation therapy in human colon cancer xenografts.  PLOS One 9(4):e93888, 2014.


Yohan D, Kim A, Korpela E, Liu S, Niu C, Wilson BC, Chin LCL.  Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy. Biomed Optics Exp 5(5): 1309, 2014.


Vesprini D, Liu S, Nam R.  Predicting high risk disease using serum and DNA biomarkers. Current Opinion in Urology 23(3): 252, 2013.


Tran E, Chow A, Goda T, Wong A, Blakely K, Rocha M, Taeb S, Hoang V, Liu SK, Emmenegger U. Context-dependent role for ATG4B as target for autophagy inhibition in prostate cancer therapy.  Biochemical and Biophysics Research Communications 441(4):726, 2013.


Ghasemi F, Wegman D, Kanoatov M, Yang B, Liu S,  Yousef G, Krylov S. Fast Direct Quantitative Analysis of Multiple miRNAs.  Analytical Chemistry 85(21):10062, 2013.

Improving patient outcomes through cancer molecular biology and biomarkers
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